Evidence for L1-associated DNA rearrangements and negligible L1 retrotransposition in glioblastoma multiforme

Table 1 Published analyses of L1-associated mutations in brain tumours

Study	Brain tumour types (sample count)	Sequencing method	L1 coverage (tumour)	Potential somatic L1-associated mutations (PCR validated)	Ref.
Iskow et al.	GBM (5), medulloblastoma (5)	L1-seq	3.6× - 6.4×	74 (0)	[30]
Lee et al.	GBM (16)	WGS	39.2×	16 (0)	[32]
Brennan et al.	GBM (42)	WGS	35.3×	0 (0)	[6]
Helman et al.	GBM (20)	WGS	40.8×	0 (0)	[35]
Tubio et al.	Glioma cell line (1)	WGS	42.6×	1 (0)	[31]
Carreira et al.	GBM (9), glioma (5)	RC-seq	43.2×–231.0×	4 (2)	–

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